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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">ADAMTS13</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="fr" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="fr" dir="ltr"><table class="infobox" style="float:right;border:1px solid #aaa;padding:3px;background-color:#f9f9f9;width:20em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;height:45px;font-weight:bold;background-color:#F5DEB3">ADAMTS13</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"></span></td></tr><tr><td colspan="4" style="text-align:center;font-size:0.8em;margin:5px 0 8px 0">Structure de la protéine ADAMTS13. Basé sur l'identifiant PDB 3GHM.</td></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#F5DEB3">Structures disponibles</th></tr><tr><th rowspan="2" style="background-color:#F5DEB3;width:43px"><a href="Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:#f9f9f9">Recherche d'orthologue : <span class=""><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=Q769J6%20or%20Q76LX8">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:Q769J6,Q76LX8">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="background-color:#F5DEB3;text-align:center"><th colspan="2">Identifiants PDB</th></tr><tr><td colspan="2" style="background-color:#f9f9f9"><p><span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3GHM">3GHM</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3GHN">3GHN</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#F5DEB3">Identifiants</th></tr><tr><th scope="row" style="background-color:#F5DEB3"><span class="">Alias</span></th><td colspan="3" style="background:#f9f9f9"><span class=""><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/1366">ADAMTS13</a></span></td></tr><tr><th scope="row" style="background-color:#F5DEB3">IDs externes</th><td colspan="3" style="background-color:#f9f9f9"><span class=""><a href="H%C3%A9ritage_mend%C3%A9lien_chez_l'humain" title="Héritage mendélien chez l'humain">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/604134">604134</a> MGI: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:2685556">2685556</a> <a href="HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=16372">16372</a> GeneCards: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=ADAMTS13">ADAMTS13</a> </span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#F5DEB3">Position du gène (<a href="Homo_sapiens" title="Homo sapiens">humain</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><span typeof="mw:File"></span></td></tr><tr><th scope="row" width="15%" style="background-color:#F5DEB3"><a href="Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#f9f9f9"><span class=""><a href="Chromosome_9_humain" title="Chromosome 9 humain">Chromosome 9 humain</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"></span><div style="position: absolute; left: 278.19620484947px; top: 2px; padding: 0;"><span typeof="mw:File"></span></div><div style="position: absolute; left: 284.2px; top: 19px; padding: 0;"><span typeof="mw:File"></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#F5DEB3"><a href="Locus" title="Locus">Locus</a></th><td rowspan="2" width="25%" style="background-color:#f9f9f9"><span class="">9q34.2</span></td><th scope="row" style="background-color:#F5DEB3">Début</th><td style="background-color:#f9f9f9"><span class="">133,414,358 <a href="Paire_de_bases" title="Paire de bases">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#F5DEB3">Fin</th><td style="background-color:#f9f9f9"><span class="">133,459,402 <a href="Paire_de_bases" title="Paire de bases">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#F5DEB3">Position du gène (<a href="Souris_de_laboratoire" title="Souris de laboratoire">souris</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><span typeof="mw:File"></span></td></tr><tr><th scope="row" width="15%" style="background-color:#F5DEB3"><a href="Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#f9f9f9"><span class="">Chromosome 2 (souris)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"></span><div style="position: absolute; left: 38.016680253427px; top: 2px; padding: 0;"><span typeof="mw:File"></span></div><div style="position: absolute; left: 44px; top: 19px; padding: 0;"><span typeof="mw:File"></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#F5DEB3"><a href="Locus" title="Locus">Locus</a></th><td rowspan="2" width="25%" style="background-color:#f9f9f9"><span class="">2|2 A3</span></td><th scope="row" style="background-color:#F5DEB3">Début</th><td style="background-color:#f9f9f9"><span class="">26,863,428 <a href="Paire_de_bases" title="Paire de bases">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#F5DEB3">Fin</th><td style="background-color:#f9f9f9"><span class="">26,899,640 <a href="Paire_de_bases" title="Paire de bases">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#F5DEB3"><a href="Expression_g%C3%A9nique" title="Expression génique">Expression génique</a></th></tr><tr><th scope="row" style="background-color:#F5DEB3"><a rel="nofollow" class="external text" href="https://bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="Chromosomes_humains" title="Chromosomes humains">Humain</a></b></th><th><b><a href="Souris_de_laboratoire" title="Souris de laboratoire">Souris</a> (orthologue)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="" style="margin:-3px"><a rel="nofollow" class="external text" href="https://bgee.org/gene/ENSG00000160323">Fortement exprimé dans</a></span></td></tr><tr><td colspan="1"><div class="" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">right lobe of liver</li><br><li style="line-height: 137%;">right hemisphere of cerebellum</li><br><li style="line-height: 137%;">right uterine tube</li><br><li style="line-height: 137%;">right frontal lobe</li><br><li style="line-height: 137%;">right testis</li><br><li style="line-height: 137%;">left testis</li><br><li style="line-height: 137%;">primary visual cortex</li><br><li style="line-height: 137%;">hypophyse</li><br><li style="line-height: 137%;">apex of heart</li><br><li style="line-height: 137%;">Brodmann area 9</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="" style="margin:-3px"><a rel="nofollow" class="external text" href="https://bgee.org/gene/ENSMUSG00000014852">Fortement exprimé dans</a></span></td></tr><tr><td colspan="1"><div class="" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">foie</li><br><li style="line-height: 137%;">dentate gyrus of hippocampal formation granule cell</li><br><li style="line-height: 137%;">morula</li><br><li style="line-height: 137%;">moelle osseuse</li><br><li style="line-height: 137%;">embryon</li><br><li style="line-height: 137%;">œsophage</li><br><li style="line-height: 137%;">hippocampus proper</li><br><li style="line-height: 137%;">primary visual cortex</li><br><li style="line-height: 137%;">Vésicule vitelline</li><br><li style="line-height: 137%;">gyrus frontal supérieur</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><span class=""><a rel="nofollow" class="external text" href="https://bgee.org/gene/ENSG00000160323">Plus de données d'expression de référence</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#F5DEB3"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><span typeof="mw:File"></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><span class=""><a rel="nofollow" class="external text" href="http://biogps.org/gene/11093/">Plus de données d'expression de référence</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#F5DEB3"><a href="Gene_Ontology" title="Gene Ontology">Gene Ontology</a></th></tr><tr><td style="background-color:#F5DEB3;font-weight:bold">Fonction moléculaire</td><td style="background-color:#f9f9f9"><div class="">
<ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005509">calcium liaison ionique</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004175">endopeptidase activity</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046872">liaison ion métal</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005178">integrin binding</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008233">activité peptidasique</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">liaison protéique</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004222">metalloendopeptidase activity</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016787">activité hydrolase</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008237">metallopeptidase activity</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008270">zinc ion binding</a></li></ul>
</div></td></tr><tr><td style="background-color:#F5DEB3;font-weight:bold">Composant cellulaire</td><td style="background-color:#f9f9f9"><div class="">
<ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005788">endoplasmic reticulum lumen</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005576">région extracellulaire</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009986">surface cellulaire</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005615">milieu extracellulaire</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031012">matrice extracellulaire</a></li></ul>
</div></td></tr><tr><td style="background-color:#F5DEB3;font-weight:bold">Processus biologique</td><td style="background-color:#f9f9f9"><div class="">
<ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007599">hémostase</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009100">glycoprotein metabolic process</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070670">response to interleukin-4</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0034341">response to interferon-gamma</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016485">protein processing</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007596">coagulation sanguine</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006508">protéolyse</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030168">platelet activation</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0034612">response to tumor necrosis factor</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007229">integrin-mediated signaling pathway</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007160">cell-matrix adhesion</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009636">réponse à une substance toxique</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043171">peptide catabolic process</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035864">response to potassium ion</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071346">cellular response to interferon-gamma</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071222">cellular response to lipopolysaccharide</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0014075">response to amine</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071353">cellular response to interleukin-4</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071356">cellular response to tumor necrosis factor</a></li></ul>
</div></td></tr><tr><td colspan="4" style="background-color:#f9f9f9;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#F5DEB3"><a href="Orthologie" title="Orthologie">Orthologues</a></th></tr><tr><th scope="row" style="background-color:#F5DEB3">Espèces</th><td style="text-align:center"><b>Homme</b></td><td style="text-align:center"><b>Souris</b></td></tr><tr><th scope="row" style="background-color:#F5DEB3"><a href="Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class=""></span></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=11093&rn=1">11093</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class=""></span></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=279028&rn=1">279028</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#F5DEB3"><a href="Ensembl" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class=""></span></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000160323;db=core">ENSG00000160323</a><br><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000281244;db=core">ENSG00000281244</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class=""></span></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000014852;db=core">ENSMUSG00000014852</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#F5DEB3"><a href="UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class=""></span></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q76LX8">Q76LX8</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class=""></span></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q769J6">Q769J6</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#F5DEB3">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_139025">NM_139025</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_139026">NM_139026</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_139027">NM_139027</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_139028">NM_139028</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001001322">NM_001001322</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001290463">NM_001290463</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001290464">NM_001290464</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001290465">NM_001290465</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#F5DEB3">RefSeq (protéine)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_620594">NP_620594</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_620595">NP_620595</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_620596">NP_620596</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001001322">NP_001001322</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001277392">NP_001277392</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001277393">NP_001277393</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001277394">NP_001277394</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#F5DEB3">Localisation (UCSC)</th><td><span class=""><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr9:133414358-133459402">Chr 9: 133.41 – 133.46 Mb</a></span></td><td><span class=""><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr2:26863428-26899640">Chr 2: 26.86 – 26.9 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#F5DEB3">Publication <a href="PubMed" title="PubMed">PubMed</a></th><td><span class=""><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class=""><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;font-size:x-small;background-color:#f9f9f9"><a href="Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;font-size:x-small;background-color:#f9f9f9"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#f9f9f9;text-align:center;font-size:x-small"><a href="https://www.wikidata.org/wiki/Q14873945" class="extiw external" title="d:Q14873945">Voir/Editer Humain</a></td><td colspan="2" style="background-color:#f9f9f9;text-align:center;font-size:x-small"><a href="https://www.wikidata.org/wiki/Q14873946" class="extiw external" title="d:Q14873946">Voir/Editer Souris</a></td></tr></tbody></table></td></tr></tbody></table>
<p>L'<b>ADAMTS13</b> (« a disintegrin and metalloprotease with thrombospondin type I repeats-13 ») est une <a href="M%C3%A9talloprot%C3%A9inase" title="Métalloprotéinase">métalloprotéinase</a> appartenant à la famille des <a href="ADAMTS" title="ADAMTS">ADAMTS</a>. Son <a href="G%C3%A8ne" title="Gène">gène</a> est <i>ADAMTS13</i> situé sur le <a href="Chromosome_9_humain" title="Chromosome 9 humain">chromosome 9 humain</a>.
</p>
<div class="mw-heading mw-heading2"><h2 id="Rôles"><span id="R.C3.B4les"></span>Rôles</h2></div>
<p>Il permet le clivage et la dégradation du <a href="Facteur_de_von_Willebrand" title="Facteur de von Willebrand">facteur de von Willebrand</a> intervenant dans la <a href="Coagulation_sanguine" title="Coagulation sanguine">coagulation sanguine</a>.
</p><p>Il pourrait également intervenir dans les <a href="Inflammation" title="Inflammation">inflammations</a>, en diminuant l'extravasation de liquides<sup id="cite_ref-Chauhan_2008_5-0" class="reference"><a href="#cite_note-Chauhan_2008-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup>.
</p>
<div class="mw-heading mw-heading2"><h2 id="En_médecine"><span id="En_m.C3.A9decine"></span>En médecine</h2></div>
<p>Le déficit en ADAMTS13, qu'il soit primaire (mutation du gène<sup id="cite_ref-Levy_2001_6-0" class="reference"><a href="#cite_note-Levy_2001-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup>) ou secondaire (par inhibition par <a href="Anticorps" title="Anticorps">anticorps</a>) cause le <a href="Purpura_thrombotique_thrombocytop%C3%A9nique" title="Purpura thrombotique thrombocytopénique">purpura thrombotique thrombocytopénique</a>, avec une accumulation de multimères de facteurs de von Willebrand. Un taux effondré d'ADAMTS13, en l'absence d'inhibiteur, serait prédicteur d'une bonne réponse aux <a href="%C3%89change_plasmatique" class="mw-redirect" title="Échange plasmatique">échanges plasmatiques</a><sup id="cite_ref-Zheng_2004_7-0" class="reference"><a href="#cite_note-Zheng_2004-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup>.
</p>
<div class="mw-heading mw-heading2"><h2 id="Notes_et_références"><span id="Notes_et_r.C3.A9f.C3.A9rences"></span>Notes et références</h2></div>
<div class="mw-references-wrap"><ol class="references">
<li id="cite_note-refGRCh38Ensembl-1"><span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000160323,">ENSG00000281244 GRCh38: Ensembl release 89: ENSG00000160323, ENSG00000281244</a> - <a href="Ensembl" title="Ensembl">Ensembl</a>, May 2017</span>
</li>
<li id="cite_note-refGRCm38Ensembl-2"><span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000014852">GRCm38: Ensembl release 89: ENSMUSG00000014852</a> - <a href="Ensembl" title="Ensembl">Ensembl</a>, May 2017</span>
</li>
<li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a> </span><span class="reference-text"><span class="ouvrage">« <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=11093"><cite style="font-style:normal;">Publications PubMed pour l'Homme</cite></a> », sur <span class="italique">National Center for Biotechnology Information, U.S. National Library of Medicine</span></span></span>
</li>
<li id="cite_note-4"><span class="mw-cite-backlink"><a href="#cite_ref-4">↑</a> </span><span class="reference-text"><span class="ouvrage">« <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=279028"><cite style="font-style:normal;">Publications PubMed pour la Souris</cite></a> », sur <span class="italique">National Center for Biotechnology Information, U.S. National Library of Medicine</span></span></span>
</li>
<li id="cite_note-Chauhan_2008-5"><span class="mw-cite-backlink"><a href="#cite_ref-Chauhan_2008_5-0">↑</a> </span><span class="reference-text">Chauhan AK, Kisucka J, Brill A, Walsh MT, Scheiflinger F, Wagner DD, <a rel="nofollow" class="external text" href="http://jem.rupress.org/content/205/9/2065.long"><i>ADAMTS13: a new link between thrombosis and inflammation</i></a>, J Exp Med, 2008;205:2065–2074</span>
</li>
<li id="cite_note-Levy_2001-6"><span class="mw-cite-backlink"><a href="#cite_ref-Levy_2001_6-0">↑</a> </span><span class="reference-text">Levy GG, Nichols WC, Lian EC et al. <a rel="nofollow" class="external text" href="http://www.nature.com/nature/journal/v413/n6855/full/413488a0.html"><i>Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura</i></a>, Nature, 2001;413:488–494</span>
</li>
<li id="cite_note-Zheng_2004-7"><span class="mw-cite-backlink"><a href="#cite_ref-Zheng_2004_7-0">↑</a> </span><span class="reference-text">Zheng XL, Kaufman RM, Goodnough LT, Sadler JE, <a rel="nofollow" class="external text" href="http://bloodjournal.hematologylibrary.org/content/103/11/4043.long"><i>Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpura</i></a>, Blood, 2004;103:4043–4049</span>
</li>
</ol></div>
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